Antinociceptive, antiinflammatory, and antipyretic. Antipyretic activity antipyretic activity of drug was measured by slightly modifying the method described by adams et al. The noblest and most lovable of the great philosophers. Analgesic and antipyretic activities of methanol extract. The antipyretic activity of ethanolic extract at a dose of 400 mgkg and 600 mgkg was tested be milk induced pyrexia in rabbits. Introduction this bon mot from osler cleverly paints the pall of apprehension felt by those who attend febrile patients at the. The subcutaneous injection of boiled milk is known to produce fever in rabbit.
Acetaminophen or paracetamol, is an analgesic with weak antiinflammatory. Therefore, the antipyretic activity of chloroform and alcoholic extracts of h. Aspirin and nsaids appear to share a similar molecular mechanism of actionnamely, inhibition of the synthesis of prostaglandins natural products of inflamed white blood cells that induce the responses in local tissue that include pain and inflammation. Moral philosophy internet encyclopedia of philosophy. Medicinal plants with potential antipyretic activity. Baruch spinoza was a dutch philosopher of portuguese sephardi origin. May 30, 2011 antipyretic activity of ethanol extracts of echinops echinatus, alhagi maurorum, fagonia cretica, cymbopogon jwarancusa and panicum turgidum form cholistan desert, pakistan was determined. Cynodon dactylon, cynodon barberi, antipyretic activity, ethanolic extract, paracetamol 1. Pendula annonaceae is an evergreen tropical tree well known for its numerous medicinal properties. Antipyretic activity petroleum ether, chloroform, alcohol, and aqueous extracts of astercantha longifolia leaves were evaluated for their antipyretic activity on the basis of their effect on brewers yeastinduced pyrexia in rats. Antipyretic simple english wikipedia, the free encyclopedia. Antipyretic and antinociceptive activity of diospyros lotus l. Among philosophers, spinoza is best known for his ethics, a monumental work. Antinociceptive, antiinflammatory, and antipyretic activity.
Introduction the plants have been used as the natural source of medicine from ancient times. The crude leaves were extracted with water, ethyl acetate and hexane. Antipyretic activity of medicinal plants of cholistan. Petroleum ether, chloroform, alcohol, and aqueous extracts of h. The purpose of this study was to evaluate the extract for antipyretic and analgesic activity, and determine its probable mechanism of action. Antipyretic activity of medicinal plants of cholistan desert. The crude extract strongly ameliorated the induced pyrexia during various assessment. However, to be clinically useful, more scientific data are needed. Analgesic and antipyretic activities of methanol extract and. These activities are essential in the symptomatic treatment of malaria fever, thereby justifying the folk use ofnefang.
Analgesics antipyretics nonsteroidal anti inflammatory. It is described in ayurvedic literature as ikshura, ikshugandha, and kokilasha having eyes like the kokila or indian cuckoo. Acetylsalicylic acid the principal effects of acetylsalicylic acid are antiinflammatory, analgesic, antipyretic and antiplatelet. In india it is commonly known as kokilaksha or gokulakanta, in sri lanka as neeramulli.
Rectal temperature was monitored at 30, 60, and 90 min postadministration of 250 and 500 mgkg of the. Caesalpinia bonducella fleming caesalpiniaceae plant is well known for its medicinal and therapeutic values in indian ayurveda. Oral doses are absorbed rapidly from the gastrointestinal. The body then works to lower the temperature, which results in a reduction in fever. Analgesic and antipyretic activities of the methanolic.
In acetic acid writhing test, the methanol extract, petroleum ether, and. That being said, spinozas views about animal ethics can be. This would be useful in its subsequent development for clinical application. Preliminary phytochemical and pharmacognostical screening. Some of the reports coincide for a given species, and, therefore, a total of 17. Antipyretic and antinociceptive activity of diospyros. Ethics, demonstrated in geometrical order usually known as the ethics, is a philosophical treatise written in latin by baruch spinoza. Be that as it may, spinozas fundamental insight in book one is that. Pyrexia was induced with bakers yeast at a dose of 10 mlkg of 30% wv. Fever is a complex physiological response triggered by infectious or aseptic stimuli. The normal body temperature of each animal was measured by digital telethermometer and recorded.
Analgesics, antipyretics, nonsteroidal antiinflammatory drugs, drugs used to treat gout, and. Pdf antiinflammatory and antipyretic activities of. The antiinflammatory activity of the various extracts was studied based on their effects on carrageenaninduced paw oedema in rats while antipyretic activity was evaluated on the basis of their effect on brewers yeastinduced pyrexia in rats. Hygrophila auriculata is belongs to the genus hygrophila whose identity as a separate genus is still debated. Comparative antipyretic activity of ethanolic extracts of some species of cynodon in rabbits. To assess the antiinflammatory, antipyretic and analgesic activities, varied. From the search, 29 hits were found with different mangrove species reporting one or more of these activities. For this, several groups of mice n 6 per group weighting 2535 g have been used. Isolation of antifungal and anticancer constituents from this plant was also reported 89.
Pyrexia was induced in rabbits by intravenous injection of 10 5 cfu of e. Effect of antipyretic activity the results of yeast induced pyrexia test of extract fractions of d. Antipyretic potential of methanolic stem bark extracts of. Hygrophila spinosa andres leaves showed significant antibacterial activity when collected between september to october, with less activity seen during other months 129. The antipyretic activity exhibited that the both petroleum ether and chloroform fraction of ethanol extract of roots possess a significant antipyretic effect in maintaining normal body temperature and reducing boiled milk induced elevated rectal temperature in rabbits and their effect are comparable to that of standard antipyretic drug aspirin. The efficacy of 100mgkg paracetamol was almost equal to that of 400mgkg of the extract at 2 hr after the drug treatment. Although the leaves of the plant is used traditionally in the treatment of pyrexia and its antipyretic related activities such as antiinflammatory and analgesic activity were. Antipyretic activity of polyalthia longifolia benth. Please note that the above slideshow is automatically created by searching flickr and does. The antipyretic activity observed at a higher dose 400 mgkg was significantly more than that at a lower dose 100 mgkg.
In the acute toxicity study, no mortality occurred. A natural pge2 inhibitory antipyretic remedy from medicinal plants with minimal toxicity is therefore essential. Antipyretic activity of ethanol extracts of echinops echinatus, alhagi maurorum, fagonia cretica, cymbopogon jwarancusa and panicum turgidum form cholistan desert, pakistan was determined. Antipyretics cause the hypothalamus to ignore increases in temperature caused by prostaglandin.
The antipyretic, antiinflammatory and analgesic activity of eenkc was evaluated in brewers yeast induced pyrexia in rats, carrageenaninduced inflammation in rats and aceticacid induced writhing in mice model. General information hygrophila auriculata is an erect, stout, branched or unbranched, annual herb growing 150cm or more tall. The study was designed to investigate the analgesic activity of methanolic extract of avicennia alba blume fam ily. Studies of the antiinflammatory and antipyretic activities of the methanolic extract of piper sarmentosum roxb. Since medicinal plants are also use to treat burns, swelling and malaria, one can expect that they might possess analgesic antiinflammatory and antipyretic activities as well.
Antipyretic activity of guduchi ghrita formulations in albino. Acute toxicity study of eenkc was performed in mice to fix the effective dose. Antipyretic activity of some nigerian medicinal plants in. The plant contains terpenoids, alkaloids, flavonoids. Invivo assessment of antipyretic and antiinflammatory.
Based on this fact as well as in view of the diversified activities reported from the genus gymnosporia, the present study was designed to evaluate the antipyretic and antiinflammatory activity of gymnosporia royleana g royleana. Satpathy3 1college of pharmacy, iftm, moradabad 244 001, up, india 2department of pharmaceutical sciences, birla institute of. Male wister rats were fasted overnight with water ad lib before the experiments. Hygrophila spinosa t ander, belonging to the family acanthaceae, is a promising medicinal plant with great economic potential. The plant contains various secondary metabolites as previously reported sen 1996, 1964. The assessment of antipyretic activity was carried out using brewers yeast induced pyrexia in wistar rats 8. Anders acanthaceae is commonly used in the traditional system of medicine for the treatment of inflammation, pain, jaundice, rheumatism, arthritis, anaemia, etc. Monographical study of biological properties of argemone. Crude extract ofzizyphus oxyphylla has shown significant activity against carrageenan induced paw edema model at 400 and 200 mgkg dose which was really found influential against inflammation. Investigation of the antiinflammatory, analgesic and. In the group of rabbits given bukharin, the decline in temperature ranged from 104. A study on antipyretic activity of capparis zeylanica linn. The antipyretic activity was evaluated by brewers yeastinduced fever models in rats.
It is a very common drug and is quite frequently mentioned in most of the samhitas, nighantus, and granthas for its effectiveness in various diseases. Antipyretic activity of methanolic extract of root of tectona grandis linn. Antipyretic activity of guduchi ghrita formulations in. Plant extracts were prepared by soaking air dried and milled plant material in ethanol for one week, followed by filtration and evaporation at 35oc. The results showed that chloroform and alcohol extracts have significant antipyretic activity, but petroleum ether and aqueous extracts failed to lower the raised body temperature in rats. The lesson to be learned from this master teacher, baruch spinoza, is that. Antipyretic activity antipyretic activity of drug lyophilized extract was measured by using brewers yeast induced pyrexia in mice. Paracetamol is similar in analgesic and antipyretic efficacy to acetylsalicylic acid. Schum heine, acanthaceae, has been traditionally used for the treatment of inflammation, pain, urinary infection, edema, gout and as a diuretic. Nonopioid analgesics with antiinflammatory activity include salicylates such as. Antipyretic, antiinflammatory and analgesic properties of.
Antipyretic effect of petroleum ether and chloroform soluble fractions of ethanol extract of the roots of vernonia cinerea was investigated. These are nonsteroidal antiinflammatory drugs nsaids used mainly as analgesics to relieve pain, but which also have antipyretic properties. The vehicle itself had a moderate antipyretic effect in the initial stages. In general, nonsteroidal antiinflammatory drugs produce their antipyretic action through the inhibition of prostaglandin synthetase within the hypothalamus 19. It also possess antipyretic activity, ethanolic extract significantly reduces fever at higher doses within 3 hrs than petroleum ether extract on brewer.
Antinociceptive and antipyretic activities from dracaena loureiri reanmongkol, w. The plant contains terpenoids, alkaloids, flavonoids, and is traditionally known as an aphrodisiac, renal tonic, and for its healthpromoting properties. Antipyretic activity of orally administered extracts of. In the present study, we examined the antiinflammatory, antipyretic and analgesic activities of c. Rats were fasted overnight with water ad libitum before the experiment. In the present study, we investigated the antiinflammatory and antipyretic activities of the petroleum ether, chloroform, alcoholic and aqueous. Although the leaves of the plant is used traditionally in the treatment of pyrexia and its antipyretic related activities such as. Antipyretic activity of methanolic stem bark extracts of h. Based on this fact as well as in view of the diversified activities reported from the genus gymnosporia, the present study was designed to evaluate the antipyretic and antiinflammatory activity of. Satpathy3 1college of pharmacy, iftm, moradabad 244 001, up, india 2department of pharmaceutical sciences, birla institute of technology, mesra, ranchi 835 215, jharkhand, india. In the present study, we investigated the antiinflammatory and antipyretic activities of the petroleum ether, chloroform, alcoholic and aqueous extracts of the leaf of this plant. The most common antipyretics in the united states are ibuprofen and aspirin. Studies on antiinflammatory, antipyretic and analgesic. Pharmacological evidence for the folk use of nefang.
To evaluate these properties, fever is induced in rabbits or rats by injection of boiled milk. Table 1 effect of guduchi ghrita prepared from male and female plants of t cordifolia on yeastinduced pyrexia at various time intervals in albino rats. Antipyretic activity of chloroform extracts of geniosporum. The results showed that chloroform and alcohol extracts have significant antipyretic. Antipyretic activity of ijpcr, octoberdecember 2012, vol 4, issue 4, 4851 page 49 toxic to the hepatic cells, glomeruli, cortex of the brain and heart muscle. Nonopioid analgesics with little or no antiinflammatory activity include paracetamol. Spinozas magnum opus, the ethics, was published posthumously in the year of his death. Medicinal properties demulcent aphrodisiac diuretic urinary tonic hepatoprotective medicinal parts aerial parts root has medicinal uses yes do not selfadminister no do no use if pregnant no legally restricted no toxicity precautions medicinal notes hygrophila spinosa has too many possible beneficial herbal uses to fully enumerate. The present investigation was carried out to study the antipyretic activity of polyalthia longifolia extracts in wistar rats against lipopolysaccharide lps induced pyrexia.
Antinociceptive and antipyretic activities of extracts and. Analgesics antipyretics nonsteroidal anti inflammatory drugs. Antipyretic and analgesic effects of the aqueous extract. Journal of chemical and pharmaceutical research, 2016, 84. The study aims to evaluate analgesic and antipyretic activities of the methanol extract and its different fractions from root of schoenoplectus grossus using acetic acid induced writhing and radiant heat tail flick method of pain models in mice and yeast induced pyrexia in rats at the doses of 400 and 200 mgkg. Analgesic, antiinflammatory and antipyretic activities of. An ant ipyretic activity is regarded as a positive side effect. A decrease in temperature can be achieved by administration of compounds with antipyretic activity. Pyrexia was induced by subcutaneously injecting 20% wv brewers yeast suspension 10 mlkg into the animals dorsum region. In contrast, the accepted safety of plant derived natural products is inspiring the world.
It is considered the best drug in terms of availability, economy, ease of administration, etc. Intraperitoneal administration of boiled milk at a dose 0. Complete works and millions of other books are available for amazon. Antiinflammatory and antipyretic activities of hygrophila. Evaluation of analgesic and antipyretic activity of marsilea trifolia blanco. Antipyretic activity of peperomia pellucidaleaves in rabbit.